It's been 10 years since the Code Blue team made their first debut on to the medical scene. Each of them have begun to make a career for themselves during this time. Aizawa Kosaku has left the emergency services at his last hospital and now works as a brain surgeon, aiming for the best performance every day. Shiraishi Megumi has been working hard as a staff leader for flight doctors at Shohoku Emergency Medical Services. Hiyama Mihoko wanted to become a flight doctor, but she left the Shohoku Emergency Medical Services to work as an obstetrician. Saejima Haruka still works as a nurse for flight doctors, pursuing her career as a top worker. Also, like Shiraishi Megumi, Fujikawa Kazuo works at the Shohoku Emergency Medical Services as a plastic surgeon specialist. Each member work face to face with life or death situations every day, and they face a new challenge which awaits them.